NEW PERSPECTIVES OF GENE THERAPY ON POLYGLUTAMINE SPINOCEREBELLAR ATAXIAS: FROM MOLECULAR TARGETS TO NOVEL NANOVECTORS

New Perspectives of Gene Therapy on Polyglutamine Spinocerebellar Ataxias: From Molecular Targets to Novel Nanovectors

Seven of the most frequent spinocerebellar ataxias (SCAs) are caused by a pathological expansion of a cytosine, adenine and guanine (CAG) trinucleotide repeat located in here exonic regions of unrelated genes, which in turn leads to the synthesis of polyglutamine (polyQ) proteins.PolyQ proteins are prone to aggregate and form intracellular inclusio

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Survey of Four Decades of Addiction Prevalence Researches in Iran

Objective: The main aim of this research custom congratulations banner is the survey of addiction and drug abuse and psychotropic drugs prevalence researches which have been done in our country in last decades Method: To do this research all addiction and drug abuse prevalence researches that have been taken place were collected and analyzed.Result

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Epidermal growth factor outperforms placebo in the treatment of diabetic foot ulcer: a meta-analysis [version 2; peer review: 2 approved]

Background: Diabetic foot ulcers (DFUs) are a life-threatening ailment caused by diabetes.Several growth factors, as well as their various combinations, have shown promising effect in aiding diabetic foot ulcer.However, contradictory or paradoxical results are often available, and debates about this issue are ongoing.Therefore, a comprehensive meta

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